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A new treatment for Cancer in Dogs and Cats

By Dr. Andrew Jones

From: Dr Andrew Jones
Author: Veterinary Secrets Revealed
Website: http://www.veterinarysecretsrevealed.com/vsr.php

Re: A NEW treatment for Cancer

//////////////////////////////////////////////

Hello again

Today’s newsletter comes to you Thanks to our
bigger community of concerned dog and cat owners.

A reader is currently dealing with something very
tragic, and very close to my heart.

Her second dog has been diagnosed with hemangiosarcoma-
this is the same cancer that killed my own dog.

Her research led her to a researcher in Washington State
who has discovered a very powerful nutraceutical, of which
I had no idea about when my own dog died of cancer.

I searched ALL over the internet, including posting
to Specialty Veterinary Sites and was basically told:
There is NOTHING you can do.

I want to Thank the dedicated member for this information,
and for sharing it with members of my Inner Circle.

Because I feel that this could benefit many of you,
I want to share this with you all.

**************************************************************************

Artemisinin could selectively kill cancer cells while
leaving normal cells unharmed

Medical Research News

Published: Wednesday, 9-Feb-2005

Researchers at the University of Washington have blended
the past with the present in the fight against cancer,
synthesizing a promising new compound from an ancient
Chinese remedy that uses cancer cells’ rapacious appetite
for iron to make them a target.

The substance, artemisinin, is derived from the wormwood
plant and has been used in China since ancient times to
treat malaria. Earlier work by Henry Lai and Narendra Singh,
both UW bioengineers, indicated that artemisinin alone could
selectively kill cancer cells while leaving normal cells unharmed.

The new compound appears to vastly improve that deadly selectivity,
according to a new study that appeared in a recent issue of the
journal Life Sciences. In addition to Lai and Singh, co-authors
include Tomikazu Sasaki and Archna Messay, both UW chemists.

“By itself, artemisinin is about 100 times more selective in
killing cancer cells as opposed to normal cells,” Lai said.
“In this study, the new artemisinin compound was 34,000
times more potent in killing the cancer cells as opposed
to their normal cousins. So the tagging process appears to
have greatly increased the potency of artemisinin’s cancer-killing
properties.”

The compound has been licensed to Chongqing Holley Holdings
and Holley Pharmaceuticals, its U.S. subsidiary, to be
developed for possible use in humans. Although the compound
is promising, officials say, potential use for people is
still years away.

In the study, researchers exposed human leukemia cells and
white blood cells to the compound. While the leukemia cells
quickly died, the white blood cells remained essentially unharmed.

The trick to the compound’s effectiveness, according to Lai,
appears to be in taking advantage of how cancer cells function.

Because they multiply so rapidly, most cancer cells need more
iron than normal cells to replicate DNA. To facilitate that,
cancer cells have inlets on their surface, known as transferrin
receptors, in greater numbers than other cells. Those receptors
allow quick transport into the cell of transferrin, an iron-carrying
protein found in blood.

In creating the compound, researchers bound artemisinin to
transferrin at the molecular level. The combination of the two
ingredients appears to fool the cancer cell.

“We call it a Trojan horse because the cancer cell recognizes
transferrin as a natural, harmless protein,” Lai said. “So the
cell picks up the compound without knowing that a bomb –
artemisinin – is hidden inside.”

Once inside the cell, the artemisinin reacts with the iron,
spawning highly reactive chemicals called “free radicals.”
The free radicals attack other molecules and the cell
membrane, breaking it apart and killing the cell.

According to Lai, that process is what initially piqued his
interest in artemisinin about 10 years ago. The wormwood
extract was used centuries ago in China, but the treatment
became lost over time. In the 1970s, it was rediscovered
as part of an ancient manuscript containing medical remedies,
including a recipe that used a wormwood extract. The
medical community soon discovered that the extract,
artemisinin, worked well against malaria, and it is
currently used for that purpose throughout Asia and Africa.

Artemisinin combats malaria because the malaria parasite
collects high iron concentrations as it metabolizes
hemoglobin in the blood. As science began to understand
how artemisinin functioned, Lai said, he began to wonder
if the process had implications for cancer treatment.

“I started thinking that maybe we could use this knowledge
to selectively target cancer cells,” he said. “So far,
the outlook appears good.”

The next step in development under the Holley licensing
agreement will likely be testing in animals and, if that
pans out, human trials to gauge the compound’s effectiveness.
The current study was funded by the Artemisinin Research
Foundation and Chongqing Holley Holdings.
 **************************************************************************

First A big Thanks to the member who posted this. I
trully hope that this helps your dog. I only wish I
knew about it 5 years ago.
Thank You to ALL of you who contribute the the
greater community by sharing information that can benefit so
many of us. This is EXACTLY what I was hoping for.
////////////////////////////////////////////// 

P.S. I have Finished my GARGANTUAN Report on
Dog and Cat Vaccines.

You get to KNOW exactly WHAT the diseases are,
The Vaccine SIDE EFFECTS, HOW to AVOID these,
PLUS what to do IF they HAPPEN.

If you’re not yet a member of my Inner Circle,
You should check out:

http://www.theonlinevet.com
It’s Your Pet. Heal Them At Home!

Best Wishes,

Dr Andrew Jones, DVM

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